Some of the mechanisms by which resveratrol has been shown to prevent colon cancer cell proliferation and invasion metastasis include regulation of key cellular signaling pathways such as NF-Κb-dependent cellular processes [14], PI3K/Akt signaling [15], modulation of histones and sirtuins [16], inhibition of cyclooxygenase-2 (Cox-2) expression [17], and alterations in gene-regulating microRNAs (miR) [18]. This evidence concerns the gene PTGS2 and colonic neoplasm.