TNF and colitis: Previous reports from our lab have shown that resveratrol is able to alter expression of certain miRs (miR-101b and miR-455) that target inflammatory mediators such as interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), and COX-2 in the dextran sodium sulfate (DSS)-induced colitis-associated tumorigenesis Apc (Min/+) mouse model [19].