However, the more sensitive mean linear intercept (Lm) measurement revealed that in Trpa1+/+ mice emphysema already started to develop at an earlier timepoint compared to the gene-deleted counterparts, Lm was significantly increased in the wildtypes after 2 months of CSE, however, not in the Trpa1−/−. The gene discussed is TRPA1; the disease is pulmonary emphysema.