Similar results were reported by Taylor and Rudd, who demonstrated that downregulation with specific small-interfering RNAs (siRNAs) or inhibition with four different GSK-3 SMIs with distinct structures, SB415286, CHIR99021, L803mts, and SB216763, can substitute for CD28 co-stimulation in the potentiation of cytotoxic CD8+ cytolytic T cells (CTL) function against lymphoma cells expressing ovalbumin peptide (OVA257–264) [94]. This evidence concerns the gene CD8A and lymphoma.