There are several publications demonstrating changes in bcl-2 in the presence of ART, either in PBMC from PLWH or in cancer cell models, but the effects of the antiretrovirals are varied [85,86,87,88,89,90,91,92], suggesting a drug-, cell- and/or disease process type-specific effect of antiretrovirals on bcl-2. The gene discussed is BCL2; the disease is cancer.