To elucidate whether curcumin blunted hepatocyte EMT to alleviate hepatic fibrosis through regulating autophagy signaling, and whether the above results depend on the activation of PPAR and inhibition of oxidative stress by curcumin in vivo, two classical murine liver fibrosis models induced by carbon tetrachloride were established. The gene discussed is PPARA; the disease is Hepatic fibrosis.