Furthermore, our findings showed that when compared with wild type mice, the phenomena of hepatic fibrosis were obvious in PPARα knockout mice, and the level of oxidative stress, the expression of Recombinant Nicotinamide Adenine Dinucleotide Phosphate Oxidase 1 (NOX1) increased, the effects induced by curcumin (enhanced autophagy, inhibited EMT and decreased hepatic fibrosis) were weakened (Fig. 7C and D). Here, NOX1 is linked to Hepatic fibrosis.