In the psWAT, higher expression of CD28, Icosl, TLRs, Il12b, Il21, Aim2, and Mmp8 (1.5–5.4 Log2FC) and lower expression of Btn1a1 (−4.3 Log2FC) in psWAT (Additional file 1: Fig. S10) suggest a proinflammatory activation/environment albeit the absence of infection. This evidence concerns the gene ICOSLG and infection.