JAK2V617F is a common synonymous variant that is frequently mutated in CHIP and age-related myeloid malignancies (Chen et al., 2012), where the JAK2 tyrosine phosphatase is constitutively activated driving a plethora of downstream pathways such as the phosphoinositide-3-kinase/Protein kinase B pathway (PI3K/AKT), Signal Transducers and Activators of Transcription (STAT) and RAS/RAF/MEK/ERK Mitogen-activated protein kinase pathways. This evidence concerns the gene AKT1 and cancer.