The possibility that the broader effects resulting from mutation of the former (such as pheochromocytomas in humans [Qin et al., 2010] and defects in insulin signalling in mice and humans [Srikantan et al., 2019]) might be attributable to dysregulation of the latter, clearly deserves further investigation. This evidence concerns the gene INS and hereditary pheochromocytoma-paraganglioma.