Additionally, the Alzheimer disease-amyloid secretase (p = 0.012), metabotropic glutamate receptor group 3 and group 1 (p = 0.015 and p = 0.017, respectively), beta 3 adrenergic receptor signalling (p = 0.019), interferon-gamma signalling (p = 0.025), corticotropin releasing factor receptor signalling (p = 0.028), apoptosis signalling (p = 0.030), 5HT4 type receptor mediated signalling (p = 0.030) and opioid proenkephalin (p = 0.030) pathways were also significantly enriched using Over Representation Analysis in WebGestalt (S3 Table). The gene discussed is CRHR1; the disease is early-onset autosomal dominant Alzheimer disease.