Moreover, our locus-specific analysis revealed changes in elements mapping to genes associated with dementia including GNB5, GNG7, and PKN3. Specifically, we have identified hypermethylation of an AluSx element at the 5’ region of the GNB5 promoter, and an AluSg element within the PKN3 promoter. The gene discussed is GNB5; the disease is dementia.