On adjusting for confounders (baseline white cell count, haemoglobin, platelet count, urea, creatinine, eGFR, albumin, ischaemic heart disease, hypertension, diabetes mellitus, cerebrovascular event, congestive cardiac failure, chronic obstructive airways disease, statin, angiotensin converting enzyme inhibitor or angiotensin II receptor blocker usage, anatomical location of the lesion and endovascular device, S1 Table), amputation-free survival was not associated with choice of antiplatelet therapy [HR 0.94, 95% CI 0.7–1.3, p = .7]. The gene discussed is ACE; the disease is chronic obstructive pulmonary disease.