In contrast, the late-stage human ovarian cancer cell lines OVCA429 and OVSAHO, harbor basal Notch3IC expression and may not readily gain additional adhesive properties in response to increased Notch3 activation, and the loss of correlation between Notch3 and survival in human stage 3 and 4 serous ovarian cancers suggests that later stage cancers upregulate Notch3-independent adhesion mechanisms. This evidence concerns the gene NOTCH3 and ovarian serous adenocarcinoma.