IL1B and osteoarthritis: IL‐1β, a member of the interleukin‐1 cytokine family, was activated by macrophages and plays a major role in the development of osteoarthritis, HIE, and liver injury (Aly, Khashaba, El‐Ayouty, El‐Sayed, & Hasanein, 2006; Hong et al., 2013), as well as induces neuronal apoptosis (Fan et al., 2018).