In addition, it was reported that perillaldehyde (PAH) attenuated cerebral ischemia/reperfusion injury in the rat brain cortex, and its neuroprotective effect was related to regulate the inflammatory response through the activation of AKT/c‐JunN‐terminal kinase (JNK) pathway (Xu, Li, Fu, & Ma, 2014). Here, MAPK8 is linked to brain ischemia.