Specifically, we investigated Kv1.3's involvement in the regulation of microglial Ca2+ signaling facilitated by the P2X4 and P2X7 receptors since similar to Kv1.3, these purinergic receptors have been associated with inflammatory microglia functions in ischemia or following LPS activation (Kettenmann et al., 2011). This evidence concerns the gene P2RX7 and ischemia.