PLG and bacterial pneumonia: Bacterial pneumonia or endotoxin (or lipopolysaccharide, LPS) exposure induce immediate (i.e., within 1 hr) release of IL‐1β dependent cytokines and chemokines and lead to enzymatic cleavage of plasminogen/plasmin into angiostatin fragments (Falcone, Khan, Layne, & Fernandes, 1998; Hamacher et al., 2002).