Tulino et al. found a significant decrease in striatal Sirt1 mRNA expression from 4 to 9 weeks in the wt group, whereas cerebellar Sirt1 mRNA expression increased significantly by 9 and 14 weeks of age in the same control group in experiments with R6/2 mouse model of HD (MRN: 204) [61]. This evidence concerns the gene SIRT1 and Huntington disease.