Parker et al. were the first who demonstrated that Sir2 overexpression and resveratrol (RESV) treatment (one of the most important non-selective Sirtuin inducer) could delay the development of neuronal dysfunction in a Caenorhabditis elegans model of HD (Htt N-terminal fragment, 128Q) in vivo [42]. This evidence concerns the gene SIRT1 and Huntington disease.