PPARGC1A and Huntington disease: Similar cerebellar predominant PGC-1α activation was induced by long-term physical exercise [47] and by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment in its acute phase [60], but not by cooling, by short-term exercise [47], or by 3-nitropropionic acid (3-NP), the toxin used for modeling HD-associated striatal damage [58, 65].