Also, next to the differential effects of KLF11 methylation on categorical disorder phenotypes, future studies may want to probe the association of KLF11 methylation with symptom subtypes/subgroups as well as with disorder-specific intermediate phenotypes, and differential DNA methylation markers of panic disorder and MDD should be explored on an epigenome-wide level by means of epigenome-wide association studies (EWAS) (cf. Shimada-Sugimoto et al. 2017; Iurato et al. 2017; Shimada et al. 2018; Ziegler et al. 2019). The gene discussed is KLF11; the disease is major depressive disorder.