A significant increase in the length of perivascular-AQP4 staining was observed in the ipsilateral and contralateral cortex of WT stroke animals compared to WT sham (Tukey’s multiple comparisons test, 95% CI [−0.4949 to −0.1666], p < 0.0001 and 95% CI −0.3330 to −0.004702], p = 0.04 respectively) (Figure 2B). Here, AQP4 is linked to stroke disorder.