To determine the possible mechanism that leads the ADSCs exosomes to increase COLGALT2 expression in osteosarcoma cells, we examined the mRNA level of COLGALT2 in ADSCs exosomes compared with MRC-5 cells exosomes, and higher COLGALT2 mRNA level was found in ADSCs exosomes (Supplementary Figure S2). The gene discussed is COLGALT2; the disease is osteosarcoma.