Another causative cis-regulatory mechanism has been constructed via integrative genomic analyses; the breast cancer-associated variant rs4415084 is located in a GATA3-binding motif of LINC02224, which refers to the differential GATA3 binding and chromatin accessibility, thereby promoting the transcription of LINC02224 and MRPS30 genes (Zhang et al., 2018). The gene discussed is MRPS30-DT; the disease is breast carcinoma.