A meta-analysis study has indicated that variant T allele of rs2107425 is correlated with a decreased risk of developing cancers (e.g., breast, ovarian, lung, and bladder cancers) (Chu et al., 2016; Wu et al., 2017), whereas variant rs2839698 is associated with an increased risk of digestive cancers (colorectal and gastric cancers) via up-regulating H19 expression; of note, there is no significant association observed between rs217727 variant and cancers susceptibility (Chu et al., 2016). The gene discussed is H19; the disease is urinary bladder cancer.