Moreover, by using allele-specific CCAT2 transgenic mice, recently, Shah et al. (2018) have revealed that overexpression of CCAT2 may lead to genomic instability and myeloid malignancies; the SNV rs6983267-specific RNA-editing induces the dysregulation of a genome-wide gene expression by down-regulating EZH2, a histone-lysine N-methyltransferase, which then results in the impairment of immune processes and development of myelodysplastic neoplasms in vivo. This evidence concerns the gene CCAT2 and myelodysplastic syndrome.