Down-regulation of LINC00673 may attenuate the interaction of PTPN11 with an E3 ubiquitin ligase PRPF19 and suppress the ubiquitin-mediated PTPN11 degradation; these processes enhance an oncogenic signaling whereas diminish STAT1-dependent anti-oncogenic signaling in cancer cells (Zheng et al., 2016). This evidence concerns the gene PTPN11 and cancer.