GATA3 and breast carcinoma: Another causative cis-regulatory mechanism has been constructed via integrative genomic analyses; the breast cancer-associated variant rs4415084 is located in a GATA3-binding motif of LINC02224, which refers to the differential GATA3 binding and chromatin accessibility, thereby promoting the transcription of LINC02224 and MRPS30 genes (Zhang et al., 2018).