The seven significant colorectal cancer associated genes shortlisted from the differentially expressed genes were CALD1, CTNNB1, CXCL14, PTCH1, CXCL8, TNFAIP3, and NNMT after mapping with PubMed, OMIM, MeSH, and PMC databases. The gene discussed is PTCH1; the disease is colorectal cancer.