MYD88 and infection: In addition, two other relevant results derived from this experimental setup are significant: (1) Caspase-11 has no or limited role in the cleavage of the cytokines induced by the infection with live tachyzoites, as single knockout BMDMs to Caspase-1 produced similar levels of the active cytokines if compared to the double knockout cells (Casp-1/11−/−); (2) MyD88, an adaptor protein for most TLRs and also the IL-1 receptor, is a crucial component of the Inflammasome activation.