Septembre-Malaterre et al. reported Curcuma longa polyphenols through decreasing oxidative stress and TNF-α, IL-6 and nuclear factor κappa B, and increasing adiponectin secretion, ameliorate obesity-related metabolic disorders (Septembre‐Malaterre et al., 2016 ▶). Here, IL6 is linked to obesity due to melanocortin 4 receptor deficiency.