ET, endovascular treatment; CSO, carotid stent occlusion; NIHSS, National Institutes of Health Stroke Scale; mTICI, modified thrombolysis in cerebral infarction; ICA, internal carotid artery; HTN, hypertension; DM, diabetes mellitus; HLD, hyperlipidemia; CAD, coronary artery disease; OSA, obstructive sleep apnea; MI, myocardial infarction; PVD, peripheral vascular disease; DAPT, dual antiplatelet; SAPT, single antiplatelet; IA-tPA, intra-arterial tissue plasminogen activator. The gene discussed is PLAT; the disease is leukodystrophy.