However, in our in vitro study, the addition of IL-6 to monocyte culture produced more potent induction of monocyte release of IL-6 and proinflammatory cytokines than did IL-1, which suggests that CART-derived IL-6 is more potent initiator than IL-1 for triggering monocyte IL-6 release and promoting CRS development in patients treated with CAR T cell therapy. This evidence concerns the gene IL1A and congenital rubella syndrome.