Traditionally OA has not been considered to be an inflammatory form of arthritis; however, there is increasing evidence to suggest that inflammation is involved in OA development and progression and, furthermore, that chondrocytes directly respond to inflammatory cues mounting a response via NF-κB leading to MMPs, COX, chemokine and cytokine expression.17 A Mediterranean diet, which is rich in olive oil, is believed to confer various health benefits, a number of which31 appear to overlap with those attributed to non-steroidal anti-inflammatory drugs. The gene discussed is NFKB1; the disease is Arthritis.