g., transfection) of stemness genes, such as OCT3, SOX2, KLF4, MYC, NOTCH1, NANOG, and LIN28, as well as epithelial-mesenchymal transition (EMT) genes (ZEB1, SNAI, VIM, TWIST, etc.), leads to stem phenotype induction and increased stem-like cancer cell activity [4, 6–14]. The gene discussed is NOTCH1; the disease is cancer.