FLT1 and neoplasm: Additionally, results in some patients showed that chemotherapy could contribute to the stages of the metastasis process: stimulate epithelial-mesenchymal transition (EMT) in tumor cells [7], stimulate invasion, intravasation, inflammation [27], circulating tumor cell (CTC) release into the blood [6], and facilitate metastasis into organs by increasing the adhesion of tumor cells to the blood vessel endothelium through increased expression of VEGFR1 [8].