In vitro, WISP1 could induce epithelial-mesenchymal transition in tumor cells, leading to increased migration and invasion, however, in vivo, WISP1 could play different roles in diverse cancer types (Ono et al., 2013; Gurbuz and Chiquet-Ehrismann, 2015; Wu et al., 2016). This evidence concerns the gene CCN4 and cancer.