In summary, we took advantage of the concerted use of fluorescence and immunogold transmission electron microscopy, co-immunoprecipitation as well as transfection and infection experiments to further characterize CAB063 as a likely type III secreted virulence-associated protein that targets HSP70 and influences host cell apoptosis by interfering with human lamin A/C at the host cell nuclear membrane. The gene discussed is LMNA; the disease is infection.