The soluble guanylyl cyclase (sGC) stimulators and activators may have a particular therapeutic potential in cardiovascular disease (Evgenov et al., 2006), and the effect of both depends on the oxidation state and heme content of sGC, and both have been shown to be effective in increasing the pool of cGMP (Evgenov et al., 2006). This evidence concerns the gene SGCB and cardiovascular disorder.