PPARGC1A and Alzheimer disease: While the PGC1α-NRF-TFAM pathway was found to be downregulated in animal model of AD (Sheng et al., 2012) showing a decreased expression level in PGC-1α (Lehman et al., 2000), as changes on SIRT1 activity (Bonda et al., 2010; Godoy et al., 2014).