SELENON and sarcoglycanopathy: Self-renewal defects causing ineffective generation of SCs were demonstrated in sarcoglycanopathy LGMD2C and 2F patients (Higuchi et al., 1999), Col6A1 knockout mice (Urciuolo et al., 2013; Gattazzo et al., 2014a), Sepn1−/− murine model, and in selenoprotein-related myopathy (SEPN1-RM) patient muscle biopsies (Sacco et al., 2010; Castets et al., 2011).