SNCA and Parkinson disease: For instance, while one study concluded that inhibiting endogenous LRRK2 kinase activity by incorporating MLi-2 into the diet of an α-synuclein PFF PD mouse model did not protect neurons from α-synuclein pathology or motor deficits (Henderson et al., 2019), another study showed that administering the HG-10-102-01 LRRK2 kinase inhibitor intraperitoneally to transgenic mice overexpressing human WT α-synuclein significantly reduced trans-axonal α-synuclein aggregates and phosphorylated α-synuclein in different brain regions of transgenic mice (Bae et al., 2018).