On the other hand, in a separate study PD LRRK2-G2019S fibroblasts had decreased p62, but showed an increase in Beclin-1, LC3, LAMP1, and Cathepsin B, culminating in an increase of autophagic flux and lysosomal activity, in basal conditions (Figure 2 and Table 1; Bravo-San Pedro et al., 2013). The gene discussed is LRRK2; the disease is Parkinson disease.