Among the identified genes, a group of four genes in the GTPases of the immunity-associated proteins family (GIMAP) – GIMAP4, GIMAP6, GIMAP7 and GIMAP8 – were strongly upregulated (fold ration >10) in the T21-BCF group compared to the T21-BC or C-BC patients (Fig. 3). The gene discussed is GIMAP6; the disease is breast cancer.