ERBB2 and ductal breast carcinoma in situ: In order to further support these results and check if GIMAPs play also a role in BC in women in general and not only in T21 patients, we evaluated the expression of GIMAP family members in 62 RNAseq libraries of 18 women without BC, 16 with DCIS (Ductal Carcinoma In Situ), 13 with triple-negative BC, and 15 with HER2 (human epidermal growth factor receptor 2) positive BC from the study of Varley et al. (Supplementary Table 2)14.