Through analysis of publically available MM cell line data (www.keatslab.org) we identified cell lines with HUWE1 mutations and subsequently confirmed HUWE1 mutations in five MM cell lines (U266, XG-1, XG-2, KMS-27, and H1112) by Sanger sequencing (Supplementary Fig. 1c). This evidence concerns the gene HUWE1 and Miyoshi myopathy.