Similarly, immunohistochemical analysis of HUWE1 expression in BM from healthy donors (n = 3), patients with MGUS (n = 3), and MM (n = 25) demonstrated a significant increase in expression of HUWE1 in MM plasma cells, compared with normal controls (p = 0.014; Fig. 1d, e). Here, HUWE1 is linked to Miyoshi myopathy.