KD of several candidate factors (e.g., sala, BG642167) in oenocytes induced cardiac arrhythmia (Supplementary Fig. 3a), similar to the KD of Cat and Sod1. On the other hand, our genetic screening identified four candidates whose KD specifically in oenocytes significantly attenuated PQ-induced cardiac arrhythmicity (Fig. 2b). The gene discussed is CAT; the disease is chronic obstructive pulmonary disease.