Conversely, our study shows significant associations between ALK1 rs2071219, rs3847859 and endoglin rs3739817 and rs10987759 polymorphisms with several cardiovascular risk factors (retinopathy, altered basal glycaemia, heart rate, LDL-cholesterol, hemoglobin levels) in a Spanish population with or without HT and DM recruited in a primary care setting. This evidence concerns the gene ENG and retinal disorder.