ENG and diabetes mellitus: Therefore, we selected four polymorphisms of these two genes, ALK1 rs2071219 and rs3847859, and endoglin rs3739817 and rs10987759, all of them associated with vascular alterations (pulmonary hypertension, arteriovenous malformations), with high prevalence in the general population and whose presence apparently does not influence the biological activity of the protein, and we analyse the association and predictive value of these polymorphic variants on cardiovascular target organ damage in at-risk populations (HT and DM patients).