Interestingly, in the latest CHD study23, POGZ was one of the top CHD genes while no DNMs were observed for SCN2A. In addition, in a recent study of 6,753 parent–offspring trios with neurodevelopmental disorders and epilepsy24, 16 DNMs were in POGZ, but only one DNM was from a patient who has both ID and epilepsy. This evidence concerns the gene SCN2A and neurodevelopmental disorder.