In contrast to other MTMs, characterized as “survival phosphatases”21,22, we demonstrated that MTMR7 reduces proliferation of CRC cells in vitro, even in the presence of activating mutations of KRAS and active insulin signalling, due to inhibition of both RAS-ERK1/2 and PI3K-AKT-mTOR signalling25. This evidence concerns the gene INS and colorectal carcinoma.