The mutations p.Asp95Asn in NBN and p.Lys425Arg in POLE segregated with both breast and ovarian cancer cases (Fig. 3a); the VUS in MSH6 p.Ser144Ile was identified in the two cases of breast cancer, one of them bilateral, in an HNPCC family (Fig. 3b). This evidence concerns the gene MSH6 and breast cancer.