The mutations p.Asp95Asn in NBN and p.Lys425Arg in POLE segregated with both breast and ovarian cancer cases (Fig. 3a); the VUS in MSH6 p.Ser144Ile was identified in the two cases of breast cancer, one of them bilateral, in an HNPCC family (Fig. 3b). The gene discussed is MSH6; the disease is ovarian cancer.