Conversely, for HNPCC, the majority of PV still resided in the traditionally screened genes, representing 9% versus the 4% with other genes, in particular, CHEK2. If we only pay attention to PVs with a clinical applicability, the designed On-Demand panel was much more efficient in the case of HBOC than HNPCC. Here, CHEK2 is linked to hereditary nonpolyposis colon cancer.