Additionally, siRNA-mediated silencing of either UNC5B or SIRT4 resulted in a significant decrease in the sensitivity to CDDP of bladder cancer 5637 and T24 cells, whereas miR-424-mediated decrease in CDDP sensitivity was partially restored by forced expression of UNC5B or SIRT4. The gene discussed is UNC5B; the disease is urinary bladder carcinoma.