CDDP treatment in bladder cancer 5637 cells induced miR-424 expression in a HIF-1α-dependent manner under normoxia, which was consistent with the recent study describing that miR-424 is implicated in the resistance to doxorubicin and etoposide of colon cancer HCT116 cells and malignant melanoma A375 cells under normoxia [15]. The gene discussed is HIF1A; the disease is urinary bladder cancer.