Systemic recurrent NTG administration has been proven to be a reliable method to produce the preclinical CM model: inducing acute and sustained hypersensitivity, which mimics the core clinical characteristics of CM; causing distinctively associated features, like photophobia, facial grimace behaviors, and upregulation of CGRP in the TNC and dura mater [15, 45]. The gene discussed is CALCA; the disease is cutaneous mastocytosis.