The Reactome pathway enrichment analysis for the SARS-CoV revealed S-glycoprotein connection with early activation of innate immune system, such as the Toll Like Receptor Cascade and TGF-β, with a strong significance (FDR < 0.0001%), while the KEGG pathway enrichment analysis revealed an association with cellular proliferation, TGF-β and other infection-related pathways (FDR < 0.0001%) (Fig. 3). Here, ART4 is linked to infection.