LGR5 was a borderline independent prognostic factor as determined with multivariable cox regression analysis for recurrence [P = 0.065, HR 2.64 (95% CI, 0.94–7.43)] (Additional Table 2) and death due to BC [P = 0.075, HR 3.08 (95% CI, 0.89–10.60)] (Additional Table 3). The gene discussed is LGR5; the disease is breast cancer.