HTR1F and migraine disorder: A separate search was conducted for “(5-HT OR serotonin) AND (mechanism OR mechanism of action) AND (blood brain barrier) AND (central penetrant) AND (physiology OR pathophysiology OR pharmacology) AND (lasmiditan OR ditan).” Results were examined to identify primary sources that address the basic pharmacology of 5-HT1F agonists or their potential role in the PNS and CNS in treating migraine.