EIF5A2 and neoplasm: We confirmed the in vitro results in metastatic tumor models of PC-3 M IE8 cells, finding that EIF5A2 sliencing markedly decreased lung metastasis of PC-3 M IE8 cells (1.2 ± 0.4) compared to the CN shRNA transfected PC-3 M IE8 cells (3.8 ± 1.2) (P < 0.05, Figure 5(a)).