APP and Alzheimer disease: Furthermore, ten weeks of treadmill training in 1.5- to 4-month-old APP/PS1 transgenic (Tg) mice is known to enhance hippocampus-associated memory and amygdala-associated neuronal function and reduce the levels of soluble Aβ in the amygdala and hippocampus and serves as a means to delay the onset of AD [1].