TP53 and lung neuroendocrine neoplasm: In addition, Simbolo et al. screened 148 lung NETs, consisting of 53 TCs, 35 ACs, 33 SCLCs, and 27 LCNECs, using next-generation sequencing and whole-exome sequencing and found MEN1 alterations are almost exclusive to low-grade carcinoids, whereas alterations in both p53 and PI3K/Akt/mTOR pathway genes were found more commonly in carcinomas, which are a higher grade of NET [63].