In addition to its constitutive expression on angiogenic endothelial cells, VEGFR2 is found to be overexpressed on several cancer cells such as breast cancer, lung cancer, pancreatic cancer, glioblastoma, gastrointestinal cancer, hepatocellular carcinoma, renal cell carcinoma, ovarian cancer, bladder cancer, and osteosarcoma cells [117]. This evidence concerns the gene KDR and cancer.