MLC1 and megalencephalic leukoencephalopathy with subcortical cysts: The diffuse brain edema characterizing the magnetic resonance imaging (MRI) of MLC patients and astrocyte vacuolation/swelling observed by histological analysis of brain tissue (see Reference [46] and the reference therein) along with alterations of chloride, potassium, and calcium fluxes reported in MLC disease models [27,48,49,50] suggest that intercellular communication and glial syncytium properties might be affected directly or indirectly by MLC1 mutations.