However, inulin (a prebiotics that promotes SCFA production) feeding increases L-cell population in HFD-fed mice and protects against obesity/T2D, while such effects of inulin disappeared in FFAR2 KO mice [24], suggesting that FFAR2 is required for acetate action to prevent HFD-induced obesity/T2D. The gene discussed is FFAR2; the disease is obesity due to melanocortin 4 receptor deficiency.