RBFOX3 and type 1 diabetes mellitus: At the molecular level, via epigenetic-histone modification butyrate converts the naive Fox3- T-cells to Fox3+ Treg cells through overexpression of FoxP3 protein, IL-10 and Helios transcription factor to provide protection against T1D (or autoimmune activity) by increasing the number of autoreactive T cells and Treg cells [178].