FFAR3 and obesity due to melanocortin 4 receptor deficiency: -Moreover, dietary (Flaxseed) fibers restructured the gut microbiota with proliferation of the genera Bifidobacterium and Akkermansia reduces fat mass and show improve tolerance to intraperitoneal and oral glucose via FFAR3.-Microbiota is associate with increase SCFA production acting through FFAR3 signaling.-Through selective FFAR3-agonist, AR420626 showed greatest efficacy of FFAR3 at distal regions of intestine to protect mice from diet induced obesity by preventing a reduction in energy expenditure induced by an HFD.