In addition, the FFAR2 KO mice model with dextran sodium sulphate (DSS)-induced colitis exhibits a decrease in colon length, an increased morbidity, an increased daily activity index (DAI), the inflammatory mediator myeloperoxidase, and a decrease in innate immunity markers such as toll-like receptors (TLR2 and TLR4) compared to their control-FFAR2WT littermate [35,71,154,157,183,188]. The gene discussed is FFAR2; the disease is colitis.