IL6 and colitis: While FFAR2 agonist reduces body weight gain, DAI, fecal Lipocalin-2 level (biomarker of intestinal inflammation), and pro-inflammatory cytokines (IL-6) and keratinocytes chemoattractant cytokine secretion from colonic mucosa of DSS-induced colitis mice, suggesting that FFAR2 agonism protects against colitis [71].