However, inulin (a prebiotics that promotes SCFA production) feeding increases L-cell population in HFD-fed mice and protects against obesity/T2D, while such effects of inulin disappeared in FFAR2 KO mice [24], suggesting that FFAR2 is required for acetate action to prevent HFD-induced obesity/T2D. This evidence concerns the gene FFAR2 and type 2 diabetes mellitus.