Widespread expression of FFAR2/3 make them play an important role in several human diseases such as type 1 and type 2 diabetes [11,25,26,27,28,29], obesity [26,30,31,32,33], inflammatory bowel disease (IBD) [34,35], Crohn’s disease [36], cardiovascular diseases [20,37,38], gout [39], asthma [6,40,41], arthritis [35], and colitis [35,42,43,44,45]. This evidence concerns the gene FFAR2 and obesity due to melanocortin 4 receptor deficiency.