-FFAR2 express in the colonic mucosa-Withdrawal of ceftriaxone antibiotic leads to reduction in SCFA concentration and increase number of conditionally pathogenic Enterobacteria, E. coli, Clostridium, Staphylococcus spp. and hemolytic bacteria in colonic gut.-FFAR2 immune regulation mechanism get hampered with increase in cytokine concentration in colonic mucosa.-Increased histopathology condition of colitis with goblet cell dysfunction, colonic dilatation and wall thickening, ultimate leads to IBD. Here, FFAR2 is linked to irritable bowel syndrome.